Am 10. Juni 1944 wurden in dieser Kirche 350 Frauen und Kinder von Mitgliedern der SS eingeschlossen und auf grausame Weise ermordet: Die SS zündeten die steinerne Kirche an und sprengten den Kirchturm, der in das Kirchenschiff einschlug. Außerdem warfen sie Handgranaten und schossen wahllos in die Menge. Alle Männer und männliche Jugendliche wurden zusammengetrieben und erschossen. Unter den 350 in der Kirche eingeschlossenen Frauen und Kindern gelang nur der 47-jährigen Marguerite Rouffanche die Flucht. Insgesamt überlebten nur 6 von 650 Einwohnern das Massaker.
On Saturday 10th June 1944 Hitlers Waffen-SS massacred the whole population of the village Oradour sur Glane in a cruel way: All the women and children were locked in the church while the village was looted. Meanwhile, the men were led to six barns and sheds where machine guns were already in place. According to the account of a survivor, the soldiers began shooting at them, aiming for their legs so that they would die slowly. Once the victims were no longer able to move, the soldiers covered their bodies with fuel and set the barns on fire. Only six men escaped; one of them was later seen walking down a road heading for the cemetery and was shot dead. In all, 190 men perished. The soldiers proceeded to the church and placed an incendiary device there. After it was ignited, women and children tried to escape through the doors and windows of the church, but they were met with machine-gun fire. A total of 247 women and 205 children died in the carnage. Only 47-year-old Marguerite Rouffanche survived. She slid out by a rear sacristy window, followed by a young woman and child. All three were shot; Marguerite Rouffanche was wounded and her companions were killed. She crawled to some pea bushes behind the church, where she remained hidden overnight until she was rescued the following morning. Another group of about twenty villagers had fled Oradour-sur-Glane as soon as the soldiers had appeared. That night, the village was partially razed.