Mesopotamia (where the human civilization was born): The town of Izeh, is a gate to Khuzistan proince of Iran. Khuzestan is part of a larger region is known under the name of Mesopotamia. Mesopotamia and the province of Khuzestan of Iran is one of the centers of ancient civilization, based around Susa. The first large scale empire based here was that of the powerful 4th millennium BC Elamites.
Archeological ruins verify the entire province of Khuzestan to be home to the Elamite civilization, a non-Semitic, and non-Indo-European-speaking kingdom, and "the earliest civilization of Persia". The name Khuzestan is derived from the Elamite (Ūvja).
In fact, in the words of Elton L. Daniel, the Elamites were the founders of the first 'Iranian' empire in the geographic sense. Hence the central geopolitical significance of Khuzestan, the seat of Iran's first empire.
Mesopotamia is widely considered to be the cradle of civilization; Bronze Age Mesopotamia included Sumer and the Akkadian, Babylonian and Assyrian empires. In the Iron Age, it was controlled by the Neo-Assyrian and Neo-Babylonian empires. The indigenous Sumerians and Akkadians (including Assyrians and Babylonians) dominated Mesopotamia from the beginning of written history (c. 3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire. It fell to Alexander the Great in 332 BC and, after his death; it became part of the Greek Seleucid Empire.
In 640 BC, the Elamites were defeated by Ashurbanipal, coming under the rule of the Assyrians who brought destruction upon Susa and Chogha Zanbil. But in 538 BC, Cyrus the Great was able to re-conquer the Elamite lands. The city of Susa was then proclaimed as one of the Achaemenid capitals. Darius the Great then erected a grand palace known as Apadana there in 521 BC. But this astonishing period of glory and splendor of the Achaemenian dynasty came to an end by the conquests of Alexander of Macedon.