The Zuiderkerk was built between 1603 and 1611, and was the first Protestant church of Amsterdam. The splendid tower was completed in 1614.
The design of the church in Amsterdam Renaissance style is by Hendrick de Keyser , who was also buried in the church in 1621. A memorial stone was placed on top of his tomb in 1921. De Keyser designed the church as a pseudo-basilica with a central nave and two lower side aisles, six bays long, with Tuscan columns, timber barrel vaults and dormers. The top gables facing north and south and crowned by balustrades remind us of the Noorderkerk and the Westerkerk. However, the rectangular shape of the windows is unique to the Zuiderkerk.
French Impressionist painter Claude Monet painted the church during a visit to the Netherlands. There is some confusion about the date of this painting, but it was probably one of 12 paintings made by Monet in 1874 during a visit to Amsterdam. The composition is centred on the church spire, with the Groenburgwal canal leading up to it in the foreground.