jeeper360, good observation.
It's completely possible that it was some sort of depot at one time. It's sitting very near an abandoned railroad bed but the current orientation of the house would not have provided a good view of the railroad through the upper windows.
I asked a few folks from that area and nobody had a definitive answer either way. The research continues.
This picture is placed too far from the tunnel. The correct location is about N39 33' 02" W78 27' 47".
This is an abandoned railroad, not road. It was built around 1901 by the Ozark and Cherokee Railroad and was bought by the Frisco Railroad in 1903. The line was abandoned in 1942.